MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function
نویسندگان
چکیده
منابع مشابه
Matrix proteoglycans: from molecular design to cellular function.
The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a variety of biological functions. Proteoglycans act as tissue organizers, influence cell growth and the maturation of specialized tissues, play a role as biological filters and modulate growth-factor activities, regulate collagen fibrillogenesis and skin tensile strength, affect tumor cell growth and invasi...
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Proteoglycans are glycosylated proteins which have covalently attached highly anionic glycosaminoglycans. Many forms of proteoglycans are present in virtually all extracellular matrices of connective tissues. The major biological function of proteoglycans derives from the physicochemical characteristics of the glycosaminoglycan component of the molecule, which provides hydration and swelling pr...
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Matrix proteoglycans are complex molecules composed of a core protein and glycosaminoglycan side chains. Once thought to be the molecular glue providing structural support and imparting biomechanical properties to lung tissue, it is now apparent that proteoglycans are important biological modifiers which regulate processes such as lung development, homeostasis, inflammation and wound healing. T...
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ژورنال
عنوان ژورنال: Annual Review of Biochemistry
سال: 1998
ISSN: 0066-4154,1545-4509
DOI: 10.1146/annurev.biochem.67.1.609